Details of the Drug

General Information of Drug (ID: DMGHQJ8)

Drug Name
N-(phosphonacetyl)-L-aspartate
Synonyms
Sparfosic acid; PALA; n-(phosphonacetyl)-l-aspartic acid; N-(Phosphonoacetyl)-L-aspartic acid; Sparfosic Acid [INN]; NSC-224131; UNII-78QVZ7RG8L; 51321-79-0; L-ASPARTIC ACID, N-(PHOSPHONOACETYL)-; N-Phosphonacetyl-L-aspartate; Phosphonacetyl-L-aspartic acid; Acidum sparfosicum [INN-Latin]; Acido sparfosico [INN-Spanish]; Acide sparfosique [INN-French]; N-(Phosphonoacetyl)-asparaginsaeure; N-(Phosphonacetyl)-L-Aspartate; 78QVZ7RG8L; (2S)-2-[(2-phosphonoacetyl)amino]butanedioic acid; Acido sparfosico; Acide sparfosique; Acidum; SPARFOSIC ACID
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 252.1
Logarithm of the Partition Coefficient (xlogp) -1.9
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 8
Chemical Identifiers
Formula
C6H7NO8P-3
IUPAC Name
(2S)-2-[[2-[hydroxy(oxido)phosphoryl]acetyl]amino]butanedioate
Canonical SMILES
C([C@@H](C(=O)[O-])NC(=O)CP(=O)(O)[O-])C(=O)[O-]
InChI
InChI=1S/C6H10NO8P/c8-4(2-16(13,14)15)7-3(6(11)12)1-5(9)10/h3H,1-2H2,(H,7,8)(H,9,10)(H,11,12)(H2,13,14,15)/p-3/t3-/m0/s1
InChIKey
ZZKNRXZVGOYGJT-VKHMYHEASA-K
Cross-matching ID
PubChem CID
46926274
UNII
78QVZ7RG8L
DrugBank ID
DB03459
TTD ID
D0L6CN

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aspartate carbamoyltransferase (CAD) TT2YT1K PYR1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [2]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [2]
Pseudomonas Aspartate carbamoyltransferase (Pseudo pyrB) TTDRBPW PYRB_PSEPU Inhibitor [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase IV (CA-IV) DTT CA4 1.58E-77 -2.02 -1.77
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MCF-7 CTRP1 10.2683 12.1819 7.4215 0.947
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SF295 CTRP1 6.8147 7.9928 4.6772 0.2843
GaMG CTRP1 7.4014 8.8522 4.5918 0.2676
LN-229 CTRP1 9.5746 12.1349 7.1024 3.9983
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HEC-265 CTRP1 6.4768 7.4802 4.7322 0.2861
HEC-251 CTRP1 6.8449 8.4245 4.5312 0.8224
HEC-6 CTRP1 6.9813 8.168 4.6769 0.2165
HEC-59 CTRP1 7.0628 8.4214 4.6183 0.339
HEC-108 CTRP1 7.1473 8.6182 4.5802 0.4134
HEC-151 CTRP1 7.2131 9.9271 6.3518 19.166
MFE-319 CTRP1 7.3392 9.1048 4.4787 0.6531
KLE CTRP1 7.6436 9.5647 4.4304 0.633
JHUEM-2 CTRP1 8.7403 10.5531 7.3237 4.2793
Ishikawa (Heraklio) 02 ER- CTRP1 6.6122 7.658 4.72 0.2552
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MC116 CTRP1 5.9891 7.0243 4.7007 0.8749
HT CTRP1 6.8133 8.1286 4.6282 0.4445
BL-70 CTRP1 6.9758 8.0545 4.7137 0.1399
KE-97 CTRP1 7.1454 8.2503 4.7064 0.1124
P3HR-1 CTRP1 7.3531 8.7024 4.6259 0.2068
Ku812 CTRP1 7.7654 9.3764 4.5416 0.2579
SU-DHL-5 CTRP1 7.924 8.6021 7.6681 4.1236
SKM-1 CTRP1 8.1539 9.5199 7.406 5.5032
AMO1 CTRP1 8.2299 9.4391 7.5057 4.3221
THP-1 CTRP1 8.3274 9.6809 7.4593 4.3895
LP-1 CTRP1 8.3977 10.0028 7.3528 5.0914
NU-DUL-1 CTRP1 8.5091 10.6519 7.1158 6.8019
KMS-11 CTRP1 8.5417 10.2274 7.3459 4.6816
U-937 CTRP1 8.7126 10.5686 7.2981 4.5752
WSU-DLCL2 CTRP1 8.8928 10.2532 7.554 2.0449
NOMO-1 CTRP1 9.2705 10.9497 7.4547 2.0346
GDM-1 CTRP1 9.6068 12.6514 6.8885 5.5623
SU-DHL-4 CTRP1 9.701 10.9935 7.6334 0.5001
OCI-AML-3 CTRP1 9.8328 11.3024 7.5721 0.6508
RPMI-8226 CTRP1 10.1117 11.6183 7.5667 0.4789
OCI-Ly10 CTRP1 10.1347 12.1491 7.377 1.2942
EJM CTRP1 10.2598 11.6772 7.6012 0.2991
MOLM-16 CTRP1 10.3809 11.7457 7.621 0.2087
PL21 CTRP1 10.4744 11.8423 7.621 0.1818
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCW CTRP1 7.5015 9.2089 4.5037 0.4687
RCC10RGB CTRP1 9.6222 10.9036 7.635 0.5521
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
DLD-1 CTRP1 6.1536 7.4536 4.604 1.2342
LS411N CTRP1 6.3026 7.7825 4.5409 1.4096
COLO205 CTRP1 6.6548 8.1189 4.5673 0.8304
GP2d CTRP1 6.9763 8.3355 4.6163 0.3896
SNU-81 CTRP1 7.0908 11.6271 5.4153 26.6154
LS513 CTRP1 7.2255 8.6738 4.5898 0.3454
SW48 CTRP1 7.2908 9.0737 4.4709 0.7176
SK-CO-1 CTRP1 7.3017 9.2772 4.3993 1.0181
C2BBe1 CTRP1 7.318 8.9987 4.509 0.5555
CW-2 CTRP1 7.3763 9.2409 6.8339 14.2275
SW403 CTRP1 7.4418 10.4704 3.9862 3.1955
SNU-C2A CTRP1 7.4463 9.4832 4.3817 0.9709
LS180 CTRP1 7.5091 8.7757 7.1797 10.5384
KM12 CTRP1 7.7185 10.5444 6.5222 15.2239
SNU-175 CTRP1 7.8541 8.7675 7.5222 5.7583
SNU-1040 CTRP1 8.0338 8.833 7.6508 3.7837
SNU-C4 CTRP1 8.0537 9.1319 7.5181 4.8963
SNU-C5 CTRP1 8.0581 9.2481 7.4636 5.3692
COLO 678 CTRP1 8.4455 15.3851 4.7128 24.4432
SW948 CTRP1 8.6598 11.751 6.6866 10.0035
CL-40 CTRP1 8.9345 15.9889 4.7978 22.1774
MDST8 CTRP1 9.0129 12.0248 6.8037 7.8627
COLO 320 CTRP1 9.1557 11.8396 6.9857 5.9407
RKO CTRP1 9.4355 10.8636 7.5704 1.0544
NCI-H508 CTRP1 9.5292 11.0309 7.5465 1.0744
HCT 116 CTRP1 9.6497 10.7518 7.7008 0.2944
HT-29 CTRP1 9.6516 11.0265 7.6011 0.675
HT115 CTRP1 9.6659 11.0036 7.6156 0.5998
HCT 8 CTRP1 9.6932 10.8373 7.6868 0.3156
CL-34 CTRP1 9.7732 11.0538 7.6397 0.4284
RCM-1 [Human ESC] CTRP1 9.8413 11.2274 7.6032 0.519
SNU-61 CTRP1 9.9103 11.5634 7.506 0.8803
LS123 CTRP1 10.3008 11.7349 7.5961 0.2958
HT-55 CTRP1 10.3385 11.5884 7.6595 0.1464
SW620 CTRP1 10.3521 12.5858 7.3023 1.4459
LoVo CTRP1 10.355 12.2326 7.438 0.8038
SW480 CTRP1 11.0713 16.4523 6.0273 8.3888
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 4 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-6 CTRP1 6.571 7.4149 4.7889 0.106
SNU-449 CTRP1 7.5209 9.534 4.3931 0.8616
Hep-G2 CTRP1 9.4117 10.9709 7.5162 1.4046
SNU-398 CTRP1 10.5543 12.2898 7.4948 0.469
Cancer Drug Sensitivity Data Curated from 91 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H1930 CTRP1 5.7234 7.602 4.2894 4.6171
BEN CTRP1 6.0589 7.1985 4.663 1.006
NCI-H1963 CTRP1 6.1918 7.9001 6.0623 27.621
NCI-H1915 CTRP1 6.3504 8.1501 4.4106 2.197
NCI-H82 CTRP1 6.5228 9.5135 3.9011 5.6681
LCLC-97TM1 CTRP1 6.5756 9.3782 3.994 4.8205
NCI-H1573 CTRP1 6.6287 8.8244 4.2675 2.6927
LCLC-103H CTRP1 6.6904 7.7875 4.7034 0.2666
NCI-H1435 CTRP1 6.7636 8.6369 4.4121 1.546
DV-90 CTRP1 6.7773 9.571 4.0228 4.1621
NCI-H522 CTRP1 6.8485 8.9511 4.3246 1.9577
SHP-77 CTRP1 6.854 8.4846 4.5121 0.904
NCI-H2029 CTRP1 6.9004 8.1684 4.6471 0.3322
NCI-H810 CTRP1 6.966 8.6031 4.5142 0.7927
NCI-H2286 CTRP1 6.977 8.4977 4.5578 0.6
NCI-H2405 CTRP1 7.0072 9.6432 4.1145 3.0734
LC-1/sq-SF CTRP1 7.0084 8.2222 4.6679 0.2281
Lu-65 CTRP1 7.0428 8.7881 4.4763 0.897
NCI-H1568 CTRP1 7.0641 9.3794 4.2527 2.0895
Calu-3 CTRP1 7.078 8.6833 4.5298 0.6382
NCI-H1793 CTRP1 7.0956 8.4815 4.6093 0.35
COR-L88 CTRP1 7.096 8.9236 4.4472 0.9842
NCI-H2009 CTRP1 7.1128 8.7872 4.5053 0.7113
HCC33 CTRP1 7.1574 8.508 4.6228 0.2843
RERF-LC-KJ CTRP1 7.1712 8.6119 4.5914 0.3664
Lu-99 CTRP1 7.2336 8.6153 4.6132 0.2785
NCI-H2126 CTRP1 7.234 8.3403 4.7066 0.095
A-549 CTRP1 7.2405 9.7179 4.1987 2.1681
NCI-H23 CTRP1 7.2828 9.2545 4.4 1.0323
DMS 273 CTRP1 7.2888 8.8852 4.5386 0.4713
COR-L279 CTRP1 7.3342 8.5679 4.6648 0.1383
KNS-62 CTRP1 7.3388 8.6531 4.6377 0.1869
NCI-H1666 CTRP1 7.3832 10.882 3.7801 4.6867
VMRC-LCD CTRP1 7.3891 8.8854 4.5758 0.3126
HARA [Human squamous cell lung carcinoma] CTRP1 7.3988 9.1987 4.4679 0.6538
NCI-H1299 CTRP1 7.4315 9.4217 4.3986 0.9094
NCI-H1355 CTRP1 7.4325 9.7196 4.2855 1.4456
NCI-H1048 CTRP1 7.4336 9.0691 4.5278 0.4289
NCI-H1975 CTRP1 7.461 9.0541 4.5432 0.3704
Calu-6 CTRP1 7.5047 9.0978 4.544 0.3491
NCI-H650 CTRP1 7.5302 9.2577 4.4971 0.4744
LXF 289 CTRP1 7.5869 9.7135 4.3531 0.9785
COLO 668 CTRP1 7.5942 9.4421 4.4556 0.5752
EPLC-272H CTRP1 7.6238 9.4798 4.4533 0.5656
EBC-1 CTRP1 7.6607 9.4179 4.4892 0.4331
NCI-H2073 CTRP1 7.6943 8.9442 7.285 8.647
NCI-H727 CTRP1 7.7354 9.8223 4.3726 0.7864
HCC44 CTRP1 7.7875 9.4601 4.5207 0.2976
ChaGo-K-1 CTRP1 7.7999 9.7621 4.4194 0.579
NCI-H1792 CTRP1 7.8223 9.5599 4.4988 0.3379
NCI-H1944 CTRP1 7.8361 9.6344 4.478 0.3862
NCI-H358 CTRP1 7.8823 10.0806 4.3361 0.825
NCI-H661 CTRP1 7.9206 9.7758 4.4595 0.4
NCI-H1437 CTRP1 7.9295 9.8696 4.4299 0.4791
HCC78 CTRP1 7.9506 9.5525 4.5467 0.1954
NCI-H1373 CTRP1 8.0196 9.845 4.4713 0.3315
Sq-1 CTRP1 8.0713 9.2571 7.4701 5.2565
NCI-H596 CTRP1 8.086 10.078 7.0718 8.7798
NCI-H460 CTRP1 8.4235 9.7844 7.4779 3.9063
NCI-H2110 CTRP1 8.4563 10.856 6.9761 8.2155
NCI-H2122 CTRP1 8.5801 9.8787 7.5381 2.9247
NCI-H1781 CTRP1 8.5948 15.1192 4.9648 22.5211
NCI-H3255 CTRP1 8.7888 11.4756 6.914 7.6302
NCI-H1105 CTRP1 8.7998 12.8394 6.2545 13.0557
COR-L23 CTRP1 9.0127 10.2871 7.6034 1.4629
SCLC-21H CTRP1 9.0466 11.8352 6.9168 6.8186
NCI-H1694 CTRP1 9.3436 10.9251 7.502 1.595
COLO 699 CTRP1 9.4931 11.3548 7.397 2.0441
HCC1359 CTRP1 9.4946 10.5448 7.7159 0.3305
COR-L51 CTRP1 9.5445 11.817 7.2258 3.1482
NCI-H2141 CTRP1 9.6122 11.2083 7.5138 1.156
HCC2108 CTRP1 9.7609 11.3672 7.5174 0.9713
NCI-H1836 CTRP1 9.8636 11.1054 7.6557 0.3247
T3M-10 CTRP1 9.9887 12.433 7.1938 2.577
NCI-H841 CTRP1 10.0497 11.6136 7.5442 0.6021
NCI-H2172 CTRP1 10.0877 11.4136 7.6303 0.2937
HCC827 CTRP1 10.1518 11.9973 7.4427 0.9538
NCI-H2081 CTRP1 10.2198 11.8449 7.5266 0.5541
NCI-H2023 CTRP1 10.2243 11.601 7.6148 0.2781
NCI-H1876 CTRP1 10.2806 11.9788 7.5017 0.6062
NCI-H441 CTRP1 10.2916 11.9485 7.5169 0.5438
HCC2935 CTRP1 10.3137 11.7471 7.5965 0.2896
HCC1195 CTRP1 10.3275 11.6896 7.6213 0.2251
CAL-12T CTRP1 10.3613 11.8941 7.5626 0.3609
NCI-H2342 CTRP1 10.4196 12.1456 7.4952 0.5424
HCC4006 CTRP1 10.4454 12.0263 7.5473 0.3662
HCC15 CTRP1 10.4716 12.2163 7.4897 0.5307
SK-LU-1 CTRP1 10.495 12.205 7.5027 0.4755
NCI-H2030 CTRP1 10.5993 12.2395 7.5292 0.349
NCI-H1755 CTRP1 10.6401 12.0483 7.609 0.1617
HCC1833 CTRP1 10.8528 12.5549 7.5115 0.2963
⏷ Show the Full List of 91 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KYSE-450 CTRP1 6.8528 8.1827 4.6239 0.4352
KYSE-410 CTRP1 7.4933 9.6314 4.3453 1.0939
KYSE-140 CTRP1 7.6506 9.8709 4.3203 1.0689
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COV318 CTRP1 6.2004 7.6255 4.5558 1.4708
EFO-21 CTRP1 6.6339 8.9978 4.1954 3.1925
OVMANA CTRP1 6.7169 8.0022 4.6365 0.4771
HEY A8 CTRP1 7.2088 8.4568 4.6588 0.1822
JHOM-1 CTRP1 7.4316 12.6292 5.2321 25.9892
SK-OV-3 CTRP1 7.4969 9.0533 4.5566 0.3187
OVKATE CTRP1 7.8134 10.4177 6.6692 13.5236
JHOS-4 CTRP1 7.8494 9.6119 4.4906 0.348
A2780 CTRP1 8.0404 10.0293 7.0582 9.0908
OVCAR-8 CTRP1 8.1036 13.1758 5.5376 21.0178
JHOC-5 CTRP1 8.1185 8.891 7.6914 3.0736
OVCAR-4 CTRP1 8.8718 14.068 5.702 16.8883
IGROV-1 CTRP1 9.2028 11.7469 7.0586 5.2213
OAW42 CTRP1 9.7358 10.7393 7.7366 0.1639
RMG-I CTRP1 9.8432 15.9398 5.4882 15.107
OV7 CTRP1 9.9615 12.0336 7.3445 1.6811
COV644 CTRP1 9.9764 11.5215 7.5489 0.6366
OVK18 CTRP1 10.1139 15.9562 5.6636 13.1784
OV-90 CTRP1 10.1152 11.6461 7.558 0.507
Caov-3 CTRP1 10.1526 11.4916 7.6268 0.2759
COV362 CTRP1 10.2156 11.6897 7.5805 0.3775
EFO-27 CTRP1 10.2286 12.1441 7.4192 0.9929
TYK-nu CTRP1 10.2535 11.8663 7.5319 0.5146
COV434 CTRP1 10.513 12.4753 7.4117 0.7917
SNU-840 CTRP1 10.8249 12.6662 7.4627 0.4333
RMUG-S CTRP1 11.1369 17.1494 5.7505 10.0212
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 10 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Capan-2 CTRP1 6.8681 10.4533 3.6787 6.5408
CFPAC-1 CTRP1 6.9573 8.6523 4.492 0.9023
HPAC CTRP1 6.9636 8.4331 4.5762 0.5383
HuP-T4 CTRP1 6.9771 8.6943 4.4843 0.9199
QGP-1 CTRP1 7.1571 8.7099 4.5511 0.5055
PaTu 8902 CTRP1 7.1731 8.6059 4.5943 0.357
SUIT-2 CTRP1 7.2137 8.6882 4.5803 0.3789
Panc 03.27 CTRP1 7.514 9.1182 4.5403 0.3551
KP-3 CTRP1 7.5638 10.6132 3.9872 2.998
Panc 10.05 CTRP1 8.0338 9.6628 4.5383 0.1898
⏷ Show the Full List of 10 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H CTRP1 7.2042 9.1481 4.4073 1.0712
NCI-H28 CTRP1 7.4642 9.6104 4.341 1.1404
NCI-H2052 CTRP1 7.592 9.41 4.4662 0.5406
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PaCa-3 CTRP1 6.8759 8.094 4.6642 0.2933
Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-MEL-1 CTRP1 4.14 8.4237 3.6772 54.2715
Hs 936.T CTRP1 6.2486 9.4514 3.7574 7.548
G-361 CTRP1 6.5654 9.0608 4.1301 3.8099
Hs 944.T CTRP1 6.8672 8.5988 4.4739 1.081
COLO 741 CTRP1 7.3354 9.3694 4.3785 1.0844
Hs 852.T CTRP1 7.4311 9.0282 4.5413 0.3897
A-375 CTRP1 8.6442 11.0268 7.03 7.0996
SK-MEL-5 CTRP1 9.0021 10.4091 7.5455 1.8883
SK-MEL-28 CTRP1 9.2038 9.9125 7.8307 0.1306
⏷ Show the Full List of 9 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
G-401 CTRP1 7.1476 10.2939 3.9088 4.2412
HT-1080 CTRP1 8.3835 13.0223 5.8423 17.7507
RKN CTRP1 8.7183 11.587 6.8096 8.7546
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
AGS CTRP1 2.5004 7.6611 2.0966 67.8987
Fu97 CTRP1 6.6858 8.7624 4.3228 2.2197
SH-10-TC CTRP1 6.8803 8.0285 4.6887 0.2253
NUGC-4 CTRP1 7.5596 9.3575 4.4727 0.5376
MKN74 CTRP1 7.6726 9.6343 4.4165 0.6647
MKN7 CTRP1 7.826 9.4663 4.5323 0.2587
SNG-M CTRP1 7.6865 9.2286 4.5641 0.2344
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-2 CTRP1 6.7285 7.9138 4.6729 0.3412
SCC-9 CTRP1 10.6908 11.9903 7.6455 0.0981
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP1 7.093 8.5581 4.5811 0.4405
5637 CTRP1 7.3953 9.656 4.2939 1.4422
KMBC-2 CTRP1 7.4352 9.7737 4.2656 1.5464
HT-1376 CTRP1 7.6897 9.7578 4.3781 0.797
RT-4 CTRP1 7.7591 9.5014 4.4962 0.3699

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.
3 Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid. Cancer Res. 1981 Mar;41(3):894-904.